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Focused on patients
Driven by discovery
Base4 is redefining RNA-targeted therapeutics through novel small molecule modulation to go after previously untreatable diseases. Powered by our revolutionary structure-based discovery platform, we are solving complicated diseases in several disease areas including neurology, oncology, and rare diseases.
...and others
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Exploiting RNA
structural dynamics
RNA structure wiggles and jiggles, forcing drug hunters to rely primarily on phenotypic methods
Base4 addresses RNA targets with a true structure-based approach


We leverage our proprietary DART Platform, a unique discovery platform that resolves dynamic atomic-resolution structures of RNA targets and screens for selective molecules against druggable RNA regions
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