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Charting the frontier of RNA-modulating small molecules


Focused on patients 
Driven by discovery

Base4 is redefining RNA-targeted therapeutics through novel small molecule modulation to go after previously untreatable diseases. Powered by our revolutionary structure-based discovery platform, we are solving complicated diseases in several disease areas including neurology, oncology, and rare diseases.




...and others

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Exploiting RNA 

structural dynamics

RNA structure wiggles and jiggles, forcing drug hunters to rely primarily on phenotypic methods

Base4 addresses RNA targets with a true structure-based approach

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We leverage our proprietary DART Platform, a unique discovery platform that resolves dynamic atomic-resolution structures of RNA targets and screens for selective molecules against druggable RNA regions


(select current partners)

In addition to our internal programs, we are engaged in strategic collaborations with like-minded pharma groups to accelerate the development of medicine.

Learn more about our partnership philosophy and the advantages of working us. 

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